abstract：:Age, haloperidol plasma levels and sex are associated with haloperidol induced motor side effects according to some lines of evidence, even though some conflicting findings mandate further research. We here report that age and sex were associated with dystonia during the early phases of treatment (p = 0.0006 and p = 0...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Giegling I,Drago A,Schäfer M,Möller HJ,Rujescu D,Serretti A

更新日期：2011-01-15 00:00:00

abstract：BACKGROUND:Abnormal vasopressin (VP) and oxytocin (OT) signaling may contribute to the altered activity of the hypothalamo-pituitary-adrenal (HPA) axis in major depression; however, the underlying mechanisms remain uncertain. This study characterized plasma levels and affinities of OT- and VP-reactive autoantibodies (a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Garcia FD,Coquerel Q,Kiive E,Déchelotte P,Harro J,Fetissov SO

更新日期：2011-01-15 00:00:00

abstract：OBJECTIVES:Seasonal affective disorder (SAD) is characterized by a mood lowering in autumn and/or winter followed by spontaneous remission in spring or summer. Bright light (BL) is recognized as the treatment of choice for individuals affected with this disease. It was speculated that BL acts on photosensitive retinal ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gagné AM,Lévesque F,Gagné P,Hébert M

更新日期：2011-01-15 00:00:00

abstract：OBJECTIVE:To examine the effectiveness and safety of adjunctive pramipexole in the treatment of stage 2 treatment-resistant major depressive disorder. METHODS:This study included patients with moderate or non-psychotic severe major depressive disorder according to DSM-IV-TR criteria despite at least two adequate treat...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Inoue T,Kitaichi Y,Masui T,Nakagawa S,Boku S,Tanaka T,Suzuki K,Nakato Y,Usui R,Koyama T

更新日期：2010-12-01 00:00:00

abstract：:Linkage studies in bipolar disorder (BPD) suggest that a susceptibility locus exists on chromosome 18p11. The myo-inositol monophosphatase 2 gene (IMPA2) maps to this genomic region. Myo-inositol monophosphatase dephosphorylates inositol monophosphate, regenerating free inositol. Lithium, a common treatment for BPD, h...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bloch PJ,Weller AE,Doyle GA,Ferraro TN,Berrettini WH,Hodge R,Lohoff FW

更新日期：2010-12-01 00:00:00

abstract：:The involvement of phospholipase A(2) (PLA(2)) in Alzheimer disease (AD) was first investigated nearly 15 years ago. Over the years, several PLA(2) isoforms have been detected in brain tissue: calcium-dependent secreted PLA(2) or sPLA(2) (IIA, IIC, IIE, V, X, and XII), calcium-dependent cytosolic PLA(2) or cPLA(2) (IV...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Schaeffer EL,da Silva ER,Novaes Bde A,Skaf HD,Gattaz WF

更新日期：2010-12-01 00:00:00

abstract：AIM:Dysregulation of the immune system may play a role in tic disorders. We screened for immune disturbances by investigating serum levels of cytokines and soluble adhesion molecules in patients with a tic disorder. METHODS:Serum levels of interleukin (IL)-2, IL-4, IL-5, IL-10, IL-12, soluble IL-2 receptor (sIL2R), tu...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bos-Veneman NG,Bijzet J,Limburg PC,Minderaa RB,Kallenberg CG,Hoekstra PJ

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:In delusional infestation (DI), as with other non-schizophrenic psychotic disorders, little is known about the neural basis and the mechanisms of antipsychotic treatment. We aimed at investigating the brain circuitry involved in DI and the role of postsynaptic D2 receptors in mediating the effects of antip...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Freudenmann RW,Kölle M,Huwe A,Luster M,Reske SN,Huber M,Lepping P,Wolf RC,Schönfeldt-Lecuona C

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:Several studies have suggested insulin resistance related to dyslipidemia and body weight in drug treated schizophrenia patients. Although, insulin resistance or impaired glucose tolerance is also reported in antipsychotic naïve schizophrenia patients, their relationship with dyslipidemic changes and body we...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dasgupta A,Singh OP,Rout JK,Saha T,Mandal S

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:γ-aminobutyrate (GABA) and Glutamate (Glu) are respectively two major inhibitory and excitatory neurotransmitters in the central nervous system and recent theories propose that both of their signaling complexes are compromised in patients with schizophrenia. METHODS:The changes in plasma GABA, Glu and GABA/...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Cai HL,Zhu RH,Li HD,Zhang XH,Hu L,Yang W,Ye HS

更新日期：2010-10-01 00:00:00

abstract：:The early development of dopaminergic pathways has been attributed importance for the aetiology of schizophrenia. Several transcription factors are involved in the survival and maturation of dopamine neurons, including LMX1A, LMX1B and PITX3. The possibility that polymorphisms in these genes may influence the developm...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bergman O,Westberg L,Nilsson LG,Adolfsson R,Eriksson E

更新日期：2010-08-16 00:00:00

abstract：BACKGROUND:Suicidal behavior has been widely accepted as familial. Its transmission cannot be explained by the transmission of psychiatric disorder alone and seems to be partly explained by the transmission of impulsive-aggressive behavior. Studies in laboratory animal have shown that mice lacking NOS1 manifest signifi...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Cui H,Supriyanto I,Asano M,Ueno Y,Nagasaki Y,Nishiguchi N,Shirakawa O,Hishimoto A

更新日期：2010-08-16 00:00:00

abstract：:Various neuroimaging techniques have revealed morphological and functional alterations in anorexia nervosa (AN), although few spectroscopic magnetic resonance studies have examined short-term weight-recovered AN patients. Subjects were 32 female adolescent patients (between 13 and 18 years old) seen consecutively in o...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Castro-Fornieles J,Garcia AI,Lazaro L,Andrés-Perpiñá S,Falcón C,Plana MT,Bargallo N

更新日期：2010-08-16 00:00:00

abstract：:Neurocardiac dysregulation has been reported in schizophrenia. Indices of heart rate variability (HRV) are useful in assessing the status of cardiac autonomic regulation. We explored within-subject changes in HRV indices in acutely ill patients with schizophrenia treated with risperidone. Sixteen medication-naïve or m...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Chang JS,Yoo CS,Yi SH,Hong KH,Lee YS,Oh HS,Jung DC,Kim YS,Ahn YM

更新日期：2010-08-16 00:00:00

abstract：:The present study examined the protective effect of hyperbaric oxygen preconditioning (HBO-PC) and the role of thioredoxin reductase (TrxR) in a post-traumatic stress disorder (PTSD)-induced rat model by using single prolonged stress (SPS). Rats were randomly divided into Sham, HBO, SPS and HBO+SPS groups. HBO-PC was ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Peng Y,Feng SF,Wang Q,Wang HN,Hou WG,Xiong L,Luo ZJ,Tan QR

更新日期：2010-08-16 00:00:00

abstract：:Both normal, non-epileptic as well as seizure-prone rodents exhibit a spectrum of anxiogenic-like behaviors in response to stressor exposure. Comparative analysis reveals that the same set of emotionality dependent measures is sensitive to both stress reactivity in normal rodents as well as stress hyperreactivity typi...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Heinrichs SC

更新日期：2010-06-30 00:00:00

abstract：:To date, no study has examined the pituitary volumes in patients with hypochondriasis. In the present study, we evaluated pituitary volumes in patients with hypochondriasis and healthy controls. Twenty individuals with hypochondriasis (ten males, ten females), aged 20 to 48 years, and healthy controls were included in...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Atmaca M,Yildirim H,Sec S,Kayali A

更新日期：2010-03-17 00:00:00

abstract：:Only two-thirds of depressive patients respond to antidepressant treatment. Recently, addition of an atypical antipsychotic drug to ongoing treatment with an antidepressant has been considered effective and well-tolerated. In the present study, we examined the effects of various atypical antipsychotic drugs as adjuvan...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yoshimura R,Ikenouchi-Sugita A,Hori H,Umene-Nakano W,Katsuki A,Hayashi K,Ueda N,Nakamura J

更新日期：2010-03-17 00:00:00

abstract：BACKGROUND:There is an interaction between the immune system and the central nervous system by means of hormones, peptides, and neurotransmitters. The aims of the present study were to determine whether the serum neopterin levels in patients with major depression (MD) differ from a healthy control group and to investig...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Celik C,Erdem M,Cayci T,Ozdemir B,Ozgur Akgul E,Kurt YG,Yaman H,Isintas M,Ozgen F,Ozsahin A

更新日期：2010-03-17 00:00:00

abstract：BACKGROUND:Brain morphometric measures from magnetic resonance imaging (MRI) have not been used to discriminate between first-episode patients with schizophrenia and healthy subjects. METHODS:Magnetic resonance images were acquired from 34 (17 males, 17 females) first-episode schizophrenia patients and 48 (24 males, 2...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Takayanagi Y,Kawasaki Y,Nakamura K,Takahashi T,Orikabe L,Toyoda E,Mozue Y,Sato Y,Itokawa M,Yamasue H,Kasai K,Kurachi M,Okazaki Y,Matsushita M,Suzuki M

更新日期：2010-02-01 00:00:00

abstract：:Several lines of evidence implicate dysfunction of glutamatergic neurotransmission in opiate dependence and withdrawal. Functional antagonists of glutamatergic system, including compounds acting on both ionotropic and metabotropic glutamate receptors (group I mGlu receptor antagonists and group II mGlu receptor agonis...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pałucha-Poniewiera A,Novák K,Pilc A

更新日期：2009-11-13 00:00:00

abstract：:A common approach to study neuronal aspects of emotional reactivity of borderline personality disorder (BPD) is to study the brain response to emotional faces with functional magnetic resonance imaging (fMRI). 10 BPD patients and 10 matched controls were submitted to an emotional discrimination task in which subjects ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Guitart-Masip M,Pascual JC,Carmona S,Hoekzema E,Bergé D,Pérez V,Soler J,Soliva JC,Rovira M,Bulbena A,Vilarroya O

更新日期：2009-11-13 00:00:00

abstract：:Several studies have shown anxiolytic effects of cannabinoids after systemic or central injections. The periaqueductal gray matter is a midbrain structure involved in the control of anxiety states. Intra-cerebral administration of cannabidiol, a phytocannabinoid, or anandamide, an endocannabinoid, into the dorsolatera...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Campos AC,Guimarães FS

更新日期：2009-11-13 00:00:00

abstract：:Power spectral analysis of electrocardiogram (ECG) R-R intervals is useful for the detection of autonomic dysfunction in various clinical disorders. Although both panic disorder (PD) and major depressive disorder (MDD) are known to have effects on the cardiac autonomic nervous system, no previous study has tested this...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kikuchi M,Hanaoka A,Kidani T,Remijn GB,Minabe Y,Munesue T,Koshino Y

更新日期：2009-11-13 00:00:00

abstract：:Prolonged cannabis use has a significant impact on health and well-being. Genetic factors are known to influence cannabis dependence, but few specific genetic markers have been identified. ABCB1 polymorphisms are known to modify drug pharmacokinetics but have yet to be studied for their role in generating and maintain...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Benyamina A,Bonhomme-Faivre L,Picard V,Sabbagh A,Richard D,Blecha L,Rahioui H,Karila L,Lukasiewicz M,Farinotti R,Picard V,Marill C,Reynaud M

更新日期：2009-10-01 00:00:00

abstract：:The interaction between genes and environment seems to be relevant for the development of Attention Deficit/Hyperactivity Disorder (ADHD), one of the most prevalent childhood psychiatric diseases. The occurrence of ADHD is typically associated with poor academic performance, probably reflecting learning difficulties a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pamplona FA,Pandolfo P,Savoldi R,Prediger RD,Takahashi RN

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:Attention-deficit/hyperactivity disorder (ADHD) is often associated with reduced IQ and high levels of externalizing behavior (EB). This study tested if DRD4 7-repeat allele and DAT1 10-repeat allele homozygosity interact in modulating correlations between IQ and EB in affected boys. METHODS:Boys (n=130) bet...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kebir O,Grizenko N,Sengupta S,Joober R

更新日期：2009-08-31 00:00:00

abstract：OBJECTIVE:Genetic factors play a critical role in the etiology of bipolar disorder (BPAD). Previous studies suggested an association between thyroid dysfunction and BPAD. We hypothesize that genetic variations in the type II deiodinase (DIO2) gene that possibly alter the bioactivity of thyroid hormones are associated w...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： He B,Li J,Wang G,Ju W,Lu Y,Shi Y,He L,Zhong N

更新日期：2009-08-31 00:00:00

abstract：:Heroin addicts can benefit from methadone substitution therapy. However, little is known about the significance of pre-exposure to opioids for psychoactive effects of methadone. We modeled some behavioral and neurobiological aspects of the opioid abuse-related phenomena in Sprague-Dawley rats, using morphine (10 mg/kg...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Taracha E,Chrapusta SJ,Lehner M,Skórzewska A,Płaźnik A

更新日期：2009-08-31 00:00:00

abstract：:Tryptophan hydroxylase-2 (TPH2) is the rate-limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and has been implicated in the pathogenesis of major depressive disorder (MDD) and in the mechanism of antidepressant action. This study aimed to investigate whether common genetic va...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Tsai SJ,Hong CJ,Liou YJ,Yu YW,Chen TJ,Hou SJ,Yen FC

更新日期：2009-06-15 00:00:00

abstract：:Depression and impaired quality of life (QOL) are frequently observed in patients suffering from a variety of diseases. In addition, it has been reported that an enhanced degradation of the serotonin precursor tryptophan may contribute to QOL deterioration in some diseases. However, it is unclear whether the correlati...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Tsai HC,Yeh TL,Hsieh MH,Lee IH,Chen KC,Chen PS,Yang YK,Yao WJ

更新日期：2009-06-15 00:00:00

abstract：:The purpose of the present study was to investigate the role of central cyclooxygenase (COX) pathways in the modulation of mechanical allodynia following compression of the left trigeminal ganglion. Experiments were carried out on male Sprague-Dawley rats mounted onto a stereotaxic frame under anesthesia. For compress...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yang GY,Lee MK,Bae YC,Ahn DK

更新日期：2009-06-15 00:00:00

abstract：:Magnolia bark and ginger rhizome is a drug pair in many prescriptions for treatment of mental disorders in traditional Chinese medicine (TCM). However, compatibility and synergism mechanism of two herbs on antidepressant actions have not been reported. The aim of this study was to approach the rationale of the drug pa...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yi LT,Xu Q,Li YC,Yang L,Kong LD

更新日期：2009-06-15 00:00:00

abstract：:Several lines of evidence suggest that the human 5-HT(7) receptor may be involved in the pharmacodynamics of risperidone and may influence clinical response of the drug. A pharmocogenetics study of this receptor may therefore be useful in developing individualized therapy. But few studies about it have been done. In t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wei Z,Wang L,Xuan J,Che R,Du J,Qin S,Xing Y,Gu B,Yang L,Li H,Li J,Feng G,He L,Xing Q

更新日期：2009-04-30 00:00:00

abstract：:A strong positive association between depression and alcoholism is evident in epidemiological studies. Curiously, the incidence of smoking (nicotine intake) is also very high among depressed individuals. Because neuronal nicotinic receptors have been implicated in mood regulation as well as in reinforcing effects of a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Tizabi Y,Getachew B,Rezvani AH,Hauser SR,Overstreet DH

更新日期：2009-04-30 00:00:00

abstract：:The central levels of endogenous tryptophan metabolite kynurenic acid (KYNA), an antagonist of N-methyl-d-aspartate (NMDA) and alpha7-nicotinic receptors, affect glutamatergic and dopaminergic neurotransmission. Here, we demonstrate that selective agonists of beta(1)-receptors (xamoterol and denopamine), beta(2)-recep...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Luchowska E,Kloc R,Olajossy B,Wnuk S,Wielosz M,Owe-Larsson B,Urbanska EM

更新日期：2009-04-30 00:00:00

abstract：:Several studies have supported the idea that ionotropic glutamate N-methyl-d-aspartate receptor (NMDA) is an important player in the etiology of psychopathologies, such as anxiety disorders and major depression. Additionally, studies have shown that ketamine induces antidepressant effects in humans as well as in roden...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Garcia LS,Comim CM,Valvassori SS,Réus GZ,Stertz L,Kapczinski F,Gavioli EC,Quevedo J

更新日期：2009-04-30 00:00:00

abstract：:Stress-related psychopathology is particularly prevalent in women, although the neurobiological reason(s) for this are unclear. Dopamine (DA) and serotonin (5-HT) systems however, are known to play important adaptive roles in stress and emotion regulation. The aims of the present study included examination of sex diff...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Duchesne A,Dufresne MM,Sullivan RM

更新日期：2009-03-17 00:00:00

abstract：:Low resting heart rate is a strong and consistent predictor of conduct disorder and chronic aggression. Explanations such as fearlessness and low arousal-induced stimulus-seeking have been offered, assuming a causal association between the phenomena, but the origin of low heart rate and its significance for understand...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Mawson AR

更新日期：2009-03-17 00:00:00

abstract：:Recent evidence indicates that the vascular endothelial growth factor (VEGF) may be involved in the neuronal mechanisms underlying both the depression aetiology and the response to pharmacological and non pharmacological antidepressant treatments. To investigate whether VEGF peripheral levels are altered in depression...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ventriglia M,Zanardini R,Pedrini L,Placentino A,Nielsen MG,Gennarelli M,Bocchio-Chiavetto L

更新日期：2009-02-01 00:00:00